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Fig. 4 | Epigenetics & Chromatin

Fig. 4

From: Hyperinsulinemia promotes aberrant histone acetylation in triple-negative breast cancer

Fig. 4

Insulin induces specific increases in H3K9ac acetylation on promoters of insulin-induced genes. a Volcano plots showing the genes differentially expressed after 3 h and b 6 h insulin treatment. Differentially expressed genes are highlighted in red. c Gene sets enriched in insulin-upregulated genes and d insulin-downregulated genes. Absolute value of Normalized enrichment score (NES) from Gene Set Enrichment Analysis (GSEA) is shown. p < 0.05. eh Box plots showing the normalized H3K9ac signal at promoters (TSS ± 1 kb) of genes upregulated and downregulated after 3 h or 6 h of insulin treatment as indicated. Significance was calculated using Kruskal–Wallis test followed by Dunn’s multiple comparisons test. Adjusted p values were calculated using Benjamini–Hochberg method. *p < 0.05, **p < 0.01, ***p < 0.001. i Genome browser screen shots showing the H3K9ac signal at TMEM201 (upregulated gene) and j GABARAPL1 (downregulated gene). Expression values (FPKM) an peak scores are shown

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