Fig. 2

Decreased chromatin accessibility and altered nucleosome organization at p63-bound OCRs and CTCF-bound OCRs in p63 mutant keratinocytes. a Top enriched motifs in Ctr-OCRs. 2492 Ctr-OCRs (targets) were used in this analysis with Mt-OCRs as background (bg). b Top enriched motifs in Mt-OCRs. 3716 Mt-OCRs (targets) were used in this analysis with Ctr-OCRs as background (bg). c Bandplots (top) and heatmaps (bottom) showing the quantification of ATAC-seq and p63 ChIP-seq signals at the 1223 p63-bound Ctr-OCRs. d Bandplots (top) and heatmaps (bottom) showing the quantification of ATAC-seq and CTCF ChIP-seq signals at the 376 CTCF-bound Ctr-OCRs. e V-plot of ATAC-seq reads showing the read length and distance from either p63 motif (top) or CTCF motif (bottom) in control and p63 mutant keratinocytes. The short fragments (< 150 bp) were indicative of nucleosome free DNA