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Fig. 5 | Epigenetics & Chromatin

Fig. 5

From: Human monocyte-to-macrophage differentiation involves highly localized gain and loss of DNA methylation at transcription factor binding sites

Fig. 5

DNA methylation changes are located in small regions which are enriched for changes in DNAseI hypersensitive sites and TF-binding sites. a Histogram depicting the number of DMRs harboring a specific amount of CpGs. b Histogram depicting the number of DMRs having similar length of region in base pairs. c Enrichment analysis for DNAseI hypersensitive sites for gain (red) and loss (blue) of DNA methylation compared to genome-wide DNAseI hypersensitive sites. d Motif analysis with HOMER for transcription factor binding sites on differential DMCs for gain (left) and loss (right) of DNA methylation. e Enrichment analysis of transcription factor binding of C/EBP and PU.1 at their motifs for gain-DMCs during monocyte-to-macrophage differentiation

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