Fig. 3

Cross-linking improves DNase-seq footprint-based prediction of TF binding. a Evaluation procedure in ROC analysis. b ROC curves for all the cross-link-DNase-seq samples are plotted using dimer-adjusted cut count data. The area under the ROC curve (auROC) values are shown along with the p values calculated by the ‘pROC’ package of R Bioconductor. Reference binding set was obtained from ChIP-seq data of LPS-activated macrophages. ROC analysis was performed for NF-κB (left: n = 99,089) and Ikaros (right: n = 165,392). See also Additional file 2: Figs. S3, S4