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Fig. 5 | Epigenetics & Chromatin

Fig. 5

From: Ovarian dysfunction following prenatal exposure to an insecticide, chlordecone, associates with altered epigenetic features

Fig. 5

Meiosis defects are associated with altered H3K4me3 and H4Ac occupancy. a Surface spreads from E15.5 ovaries in zygotene stage and somatic cells from control (first row) and CD-exposed mice (second row) were immunostained with anti-H3K4me3 (red) and anti-SYCP3 (green) antibodies (63X magnification). c Surface spreads from E15.5 ovaries in zygotene stage and somatic cells from control and CD-exposed mice were immunostained with anti-H4 (red) and anti-SYCP3 (green) antibodies. b, d Quantitative analysis of anti-H3K4me3 and H4Ac intensities in zygotene stages of oocytes and in somatic cells. The analysis was performed on at least 20 oocytes from four replicates for each group, n = 4 for each group, *p < 0.05, **p < 0.01, ***p < 0.001, t test

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