Fig. 2

Mechanisms of recruitment of the Ep400/Tip60 complex. The Ep400/Tip60 complex, involved in loading and acetylation of the histone variant H2A.Z, can be recruited to its target genomic sites via interactions with a transcription factors (TFs) or b subunits of the pre-initiation complex (PIC) composed of general transcription factors (GTF; TFIIA, TFIIB, TFIID, TFIIE, TFIIF and TFIIH) and RNA polymerase II (RNAPII). In addition, the Ep400/Tip60 complex can be recruited to its target genomic sites via interactions with posttranslationally modified histone proteins, for example: c MRG15 binds to H3K4me1 or H3K4me3 [122], while Tip60 binds to H3K4me1 via its chromodomain [118]. d GAS41 binds to H3K14ac, H3K27ac or H3K122suc using its YEAST domain [123,124,125,126,127]. For simplicity reasons, only the Ep400/Tip60 complex is shown; however, similar mechanisms of recruitment can be used by the SRCAP complex. TFBS transcription factor binding site