Fig. 5

Chromatin remodeller binding at chromatin architectural features. a–c Enrichment of chromatin remodeller binding sites at the binding sites of key chromatin architectural proteins as defined by their ChIP-seq-binding profiles. Significant enrichment is defined as a score above one and significantly depleted as below one with Benjamini–Hochberg adj p-value, ***p < 0.001 or **p <0.05. d Percentage of remodeller binding sites in TADs, TAD boundaries and unorganised chromatin. e Schematic diagram depicting TADs in linear and 3D space with an inactive loop condensing chromatin and an active loop bringing an enhancer (orange oval) and promoter (blue flag) within close proximity. f–h Enrichment of chromatin remodeller binding at anchor points of chromatin loops defined by Hi-C and histone modification data as containing an active promoter or enhancer or neither. Significant enrichment is defined as a score above one and significantly depleted as below one with Benjamini–Hochberg adj p-value, ***p <0.001 or **p < 0.05. i The KLK region on chromosome 19 and a regions on chromosome 1 containing active loops (pink arcs) with Group 1 remodeller binding sites at the long-range loop anchors shaded in grey, with complementary three-dimensional view from Rondo (Rondo.ws)