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Fig. 4 | Epigenetics & Chromatin

Fig. 4

From: The long non-coding RNA Kcnq1ot1 controls maternal p57 expression in muscle cells by promoting H3K27me3 accumulation to an intragenic MyoD-binding region

Fig. 4

Kcnq1ot1 expression is restricted to the paternal allele and does not decrease during differentiation. Allele-specific RT-qPCR analysis of maternal and paternal Kcnq1ot1 (M-Kcnq1ot1 and P-Kcnq1ot1, respectively) performed in polymorphic fibroblasts (C57B/6 female × SD7 male) infected with the MyoD retroviral vector and analyzed in undifferentiated (U) and differentiated (D) cells. Values, normalized to Tbp expression, are the mean ± SEM of four independent experiments. Statistical significance: p value < 0.01 (**)

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