Fig. 5

H3K4 methylation changes during CFC. In the CFC paradigm, naive mice are subjected to either a novel context (Context) or this novel context and an electric foot shock (Context–Shock) to precipitate formation of contextual and associative memories, respectively. Gupta et al. [5] dissected out the CA1 region of the hippocampus from these mice and subjected the tissues to ChIP-qPCR using primers to the promoters of learning genes. Increases in H3K4me3 intensity levels were observed at Bdnf and Zif268 promoters in Context–Shock mice. However, it is currently unknown whether or not H3K4me3 breadth undergoes similar changes at learning-related genes in this paradigm