Fig. 2

Annotations of the DMRs. Based on their genomic locations, DMRs identified in the comparison: a GBM⁵⁰ versus GBM¹⁰⁰ (p ≤ 0.001); b GBM³ versus GBM¹⁰⁰ (p ≤ 0.001); c GBM^0.2 versus GBM¹⁰⁰ (p ≤ 0.001); and d GBM^0.2 versus GBM¹⁰⁰ (adjusted. p ≤ 0.05) were classified into promoters, exons, introns, UTRs, downstream regions, distal intergenic regions and super enhancers using the ChIPSeeker package (n = 3 tumours per group). DMR-overlapping regions in brown signify promoter regions, violet-red indicates exons, green indicates introns, blue indicates promoters, teal represents UTRs, blue represents downstream regions, orange indicates intergenic regions, and pink indicates super enhancers. The percentage of each group is indicated in the key to each figure