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Fig. 5 | Epigenetics & Chromatin

Fig. 5

From: Genomic meta-analysis of the interplay between 3D chromatin organization and gene expression programs under basal and stress conditions

Fig. 5

Differential promoter interactions versus differential gene expression. a Genes located in the A compartment in both MCF7 and K562 cell lines (AA genes) were divided into four groups according to the engagement of their promoters in chromatin interactions in the two cell lines (as indicated by RNA PolII ChIA-PET data). Gene sets 00, 01, 10, and 11 correspond, respectively, to the set of genes whose promoter is engaged in chromatin interactions in either none, only K562, only MCF7 or both cell lines. Expression levels in both cell lines are plotted for each gene set. Color indicates gene density. b Distribution of fold change in gene expression (log2) between MCF7 and K562 was calculated for each gene set. Highly significant association between differential gene expression and differential involvement of promoters in chromatin interaction was observed. P values are computed using Wilcoxon’s test

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