Fig. 2

Genome-wide alterations in histone modification statuses after 20E treatment. a Histone modification statuses are altered throughout the genome after 20E treatment. Regions showing a more than twofold increase (red dots) or decrease (green dots) in signals between 20E- and DMSO-treated groups were defined as having increased or decreased histone modifications, respectively. Dark dots represent the regions that showed less than twofold changes. The p value of ordinate from DEseq 2 represented the probability of difference. b IGV genome browser tracks of the Hr3 locus with data for indicated histone modifications and RNA-seq. “+” and “−” indicate the presence and absence of 20E treatment, respectively. The square indicated the region that H3K27ac modification changed drastically after 20E treatment. c Histone modification collaboration in different genome regions. “H3K4me3&H3K27ac” represented the H3K4me3 sites that overlapped with H3K27ac sites. “H3K4me1&H3K27ac” represented the H3K4me1 sites that overlapped with H3K27ac sites. “H3K4me3” represented the H3K4me3 sites that did not overlap with H3K27ac sites. “H3K4me1” represented the H3K4me1 sites that did not overlap with H3K27ac sites