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Fig. 3 | Epigenetics & Chromatin

Fig. 3

From: DNA methylation analysis on purified neurons and glia dissects age and Alzheimer’s disease-specific changes in the human cortex

Fig. 3

Braak stage analysis in neuron and glia. a Genomic p value distribution for the Braak stage progression analysis in neurons. b Genomic p value distribution for the Braak stage progression analysis in glia. c Overlap for the top 1000 ranking Braak-DMCGs from neuron and glia. d Overlap of top 1000 Braak-DMCGs and top 1000 aging-DMCGs from neuron, 10% of Braak-DMCGs are ct-DMCGs. e Same as d but for glia top DMCGs. Compared to neuron there are more ct-DMCGs among top Braak-DMCGs in glia. f Distribution across genomic regions of top 1000 Braak-DMCGs from neuron and glia. CpGs were classified as hypo- or hypermethylated in respect to methylation change from 8 youngest CTRLs to 8 oldest Braak stage VI samples. Most methylation changes are at gene body, promoters and 1st exon regions. g Similar to f but in relation to array design. h Methylation changes from 8 youngest CTRLs to 8 oldest Braak stage VI samples for top 1000 Braak-DMCGs in neurons and glia, respectively. Boxes colored as in f (color figure online)

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Epigenetics & Chromatin

ISSN: 1756-8935