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Fig. 4 | Epigenetics & Chromatin

Fig. 4

From: Age-related DNA methylation changes are tissue-specific with ELOVL2 promoter methylation as exception

Fig. 4

Characterization of loss-aDMPs. a Percentage and odds ratios of aDMPs in CGIs, shores and non-CGIs. Blue enriched, red depleted, grey non-significant. b Number of tissues an aDMPs was identified in. c Enrichment of gain-aDMPs in chromatin segmentations expressed as an odds ratio, grey non-significant enrichment. d Frequency of genes (y axis) against the number of tissues genes were identified in (x axis). e Expression of genes (y axis, RPKM) near loss-aDMPs per tissue (x axis). Abbreviations: TssA active TSS, TssAFlnk flanking active TSS, TxFlnk transcr. at gene 5′ and 3′, Tx strong transcription, TxWk weak transcription, EnhG genic enhancers, Enh enhancers, ZNF/Rpts ZNF genes + repeats, Het heterochromatin, TssBiv bivalent/poised TSS, BivFlnk flanking bivalent TSS/Enh, EnhBiv bivalent enhancer, ReprPC repressed polycomb, ReprPCWk weak repressed polycomb, Quies quiescent/low

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