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Fig. 3 | Epigenetics & Chromatin

Fig. 3

From: Age-related DNA methylation changes are tissue-specific with ELOVL2 promoter methylation as exception

Fig. 3

Characterization of gain-aDMPs. a Frequency of aDMPs (y axis) against the number of tissues the aDMPs was identified in (x axis). b Enrichment of gain-aDMPs in chromatin segmentations expressed as an odds ratio, grey non-significant. c Percentage (top) and odds ratios (bottom) of aDMPs in CGIs, shores and non-CGIs. Blue enriched, red depleted, grey non-significant. d Percentage (top) and odds ratios (bottom) of aDMPs in EZH2 binding sites (ChIP-seq, any cell type, ENCODE). Blue enriched, red depleted, grey non-significant. e Frequency of CpG islands (y axis) against the number of tissues a CpG island was identified in (x axis). f Frequency of genes (y axis) against the number of tissues a gene was identified in (x axis). g Expression (y axis, RPKM) of genes near gain-aDMPs per tissue (x axis). Abbreviations: TssA active TSS, TssAFlnk flanking active TSS, TxFlnk transcr. at gene 5′ and 3′, Tx strong transcription, TxWk weak transcription, EnhG genic enhancers, Enh enhancers, ZNF/Rpts ZNF genes + repeats, Het heterochromatin, TssBiv bivalent/poised TSS, BivFlnk flanking bivalent TSS/Enh, EnhBiv bivalent enhancer, ReprPC repressed polycomb, ReprPCWk weak repressed polycomb, Quies quiescent/low

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