Fig. 1
From: Same agent, different messages: insight into transcriptional regulation by SIN3 isoforms
Schematic representation of SIN3 isoforms in different species. This schematic was generated using the batch-CD (conserved domain) search interface from NCBI [67, 68]. The scale at the top represents amino acid positions in the protein. PAH domains are paired amphipathic helix domains involved in protein–protein interaction. HDAC interaction domain (HID), also known as Sin3 family corepressor domain, is involved in interaction with HDACs. Sin3a_C domain is a conserved domain found in the SIN3 protein family at the C-terminus, downstream of the Sin3 family corepressor domain. This region contains a protein–protein interaction domain and a region of high sequence conservation with unknown function, previously known as PAH4 and HCR, respectively. D.m., Drosophila melanogaster, M.m., Mus musculus