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Fig. 6 | Epigenetics & Chromatin

Fig. 6

From: Modulation of nucleosomal DNA accessibility via charge-altering post-translational modifications in histone core

Fig. 6

Explanation for the counterintuitive net stabilizing effect of H4K77Ac on the nucleosome, which makes the global DNA less accessible. In the intact nucleosome, the positively charged H4K77 (blue spheres) is in close proximity of H2BR92 (green spheres): their repulsion destabilizes the nucleosome, favoring more open states with higher DNA accessibility. This destabilizing interaction is eliminated when an acetylation of H4K77 neutralizes its positive charge

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Epigenetics & Chromatin

ISSN: 1756-8935