Fig. 1

Ube3a/UBE3A is highly expressed in mouse and human CNS tissues. a Ube3a transcript levels in adult Ube3a ^m+/p+ (n = 4) and Ube3a ^m+/p− (n = 3) CNS (cortex, hippocampus) and non-CNS (N-CNS; heart, kidney, liver, and lung) tissues. Levels are shown as the ratio of expression in tissues relative to heart. b Ube3a protein levels in adult Ube3a ^m+/p+ (n = 4) and Ube3a ^m+/p− (n = 3) CNS (cerebellum, cortex, hippocampus) and non-CNS (heart, liver, and lung). Levels are shown as the ratio of expression in tissues relative to heart. c Normalized FPKM values of total Ube3a transcripts and d maternal and paternal Ube3a transcripts in B6D2F1 mouse hippocampus, thymus, liver, lung, and heart (n = 6). e, f Normalized FPKM values of UBE3A transcripts in adult human tissues (GTEx: n ≥ 30; Fagerberg et al.: n = 3). Abbreviations n.s., not significant; *p < 0.05; **p < 0.001. Individual data points provided with mean (gray bar chart) and 95% confidence intervals