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Table 2 Differentially methylated genomic regions between Nicoyans and non-Nicoyans

From: Differential DNA methylation and lymphocyte proportions in a Costa Rican high longevity region

Genomic sequencea # CpGs Min FDR Max Δβ Mean Δβ Associated gene DMR length (bp) Genomic region Gene ontology
chr5:102898223-102898733 6 1.0E−11 −0.07 −0.05 NUDT12 511 Promoter NAD + diphosphatase activity; NADH pyrophosphatase activity
chr4:132896266-132897018 6 4.9E−08 −0.09 −0.06 753 Intergenic
chr5:180643432-180643713 3 1.9E−05 −0.05 −0.05 282 Intergenic
chr7:155832831-155832992 3 2.9E−04 0.06 0.05 162 Intergenic
chr11:68658383-68658836 3 7.3E−04 −0.09 −0.08 MRPL21 454 3′ end Poly(A) RNA binding, ribosomal protein
chr6:6894084-6894182 3 5.3E−4 0.06 0.05 99 Intergenic
chr7:64034943-64035529 3 2.4E−03 0.07 0.06 LOC100128885 593 Promoter
chr12:130707332-130707407 3 2.6E−03 0.07 0.05 76 Intergenic Wnt-protein binding
chr3:128215433-128216122 3 1.7E−03 −0.06 −0.05 GATA2-AS1 690 Intragenic Enhancer sequence-specific binding, chromatin/transcription factor/C2H2 zinc finger binding
chr5:42924215-42924694 4 2.6E−03 0.07 0.05 480 Intergenic
chr1:152161237-152162507 8 2.1E−06 −0.07 −0.05 113 Intergenic
chr16:3988694-3988869 3 1.9E−02 −0.07 −0.05 176 Intergenic
chr6:28446794-28447115 5 1.3E−02 0.06 0.06 tRNA-Leu 322 Promoter
chr19:12876846-12877188 4 3.6E−02 −0.14 −0.11 HOOK2 343 Intragenic Kinase modulator; membrane traffic protein
chr17:1133546-1133706 3 3.5E−02 −0.07 −0.05 ABR 161 Promoter Transcription factor; protein binding; guanyl-nucleotide exchange factor
chr15:81410745-81411066 4 2.3E−02 0.09 0.06 C15orf26 322 Intragenic
chr2:74357527-74358223 5 2.0E−02 0.08 0.06 BOLA3 697 3′ end Production of iron–sulfur clusters
chr1:205818956-205819609 8 2.2E−02 −0.08 −0.07 PM20D1 654 Promoter Deacetylase, metalloprotease
chr8:599525-600940 8 2.7E−04 −0.12 −0.05 ERICH1 1416 Intragenic
chr5:135415693-135416613 16 1.1E−03 −0.09 −0.06 VTRNA2-1 921 Promoter Potential tumor suppressor
  1. DMR differentially methylated region
  2. Δβ: (Delta beta; absolute mean or max difference of β values between groups (Nicoya–non-Nicoya)
  3. aGenome coordinates from Human Genome GRCh37/hg19 Assembly