Table 2 Differentially methylated genomic regions between Nicoyans and non-Nicoyans
From: Differential DNA methylation and lymphocyte proportions in a Costa Rican high longevity region
Genomic sequencea | # CpGs | Min FDR | Max Δβ | Mean Δβ | Associated gene | DMR length (bp) | Genomic region | Gene ontology |
|---|---|---|---|---|---|---|---|---|
chr5:102898223-102898733 | 6 | 1.0E−11 | −0.07 | −0.05 | NUDT12 | 511 | Promoter | NAD + diphosphatase activity; NADH pyrophosphatase activity |
chr4:132896266-132897018 | 6 | 4.9E−08 | −0.09 | −0.06 | – | 753 | Intergenic | – |
chr5:180643432-180643713 | 3 | 1.9E−05 | −0.05 | −0.05 | – | 282 | Intergenic | – |
chr7:155832831-155832992 | 3 | 2.9E−04 | 0.06 | 0.05 | – | 162 | Intergenic | – |
chr11:68658383-68658836 | 3 | 7.3E−04 | −0.09 | −0.08 | MRPL21 | 454 | 3′ end | Poly(A) RNA binding, ribosomal protein |
chr6:6894084-6894182 | 3 | 5.3E−4 | 0.06 | 0.05 | – | 99 | Intergenic | – |
chr7:64034943-64035529 | 3 | 2.4E−03 | 0.07 | 0.06 | LOC100128885 | 593 | Promoter | – |
chr12:130707332-130707407 | 3 | 2.6E−03 | 0.07 | 0.05 | – | 76 | Intergenic | Wnt-protein binding |
chr3:128215433-128216122 | 3 | 1.7E−03 | −0.06 | −0.05 | GATA2-AS1 | 690 | Intragenic | Enhancer sequence-specific binding, chromatin/transcription factor/C2H2 zinc finger binding |
chr5:42924215-42924694 | 4 | 2.6E−03 | 0.07 | 0.05 | – | 480 | Intergenic | – |
chr1:152161237-152162507 | 8 | 2.1E−06 | −0.07 | −0.05 | – | 113 | Intergenic | – |
chr16:3988694-3988869 | 3 | 1.9E−02 | −0.07 | −0.05 | – | 176 | Intergenic | – |
chr6:28446794-28447115 | 5 | 1.3E−02 | 0.06 | 0.06 | tRNA-Leu | 322 | Promoter | – |
chr19:12876846-12877188 | 4 | 3.6E−02 | −0.14 | −0.11 | HOOK2 | 343 | Intragenic | Kinase modulator; membrane traffic protein |
chr17:1133546-1133706 | 3 | 3.5E−02 | −0.07 | −0.05 | ABR | 161 | Promoter | Transcription factor; protein binding; guanyl-nucleotide exchange factor |
chr15:81410745-81411066 | 4 | 2.3E−02 | 0.09 | 0.06 | C15orf26 | 322 | Intragenic | – |
chr2:74357527-74358223 | 5 | 2.0E−02 | 0.08 | 0.06 | BOLA3 | 697 | 3′ end | Production of iron–sulfur clusters |
chr1:205818956-205819609 | 8 | 2.2E−02 | −0.08 | −0.07 | PM20D1 | 654 | Promoter | Deacetylase, metalloprotease |
chr8:599525-600940 | 8 | 2.7E−04 | −0.12 | −0.05 | ERICH1 | 1416 | Intragenic | – |
chr5:135415693-135416613 | 16 | 1.1E−03 | −0.09 | −0.06 | VTRNA2-1 | 921 | Promoter | Potential tumor suppressor |