Fig. 1
From: Links between DNA methylation and nucleosome occupancy in the human genome
Genome-wide nucleosomal DNA sequence and methylation patterns in leukocytes and IMR90 cells. a For the in vitro MNase-seq data from leukocytes, average occurrences of select dinucleotides were computed from forward and reverse complement sequences aligned to nucleosome midpoints. Using BS-seq and MNase-seq data from leukocytes, average occurrences of CpGs (b), methylated and unmethylated CpGs (c, d) and mCpG/CpG fractions (e, f) were computed for both the in vitro and in vivo libraries from forward and reverse complement sequences aligned to nucleosome midpoints. Using MNase-seq and NOMe-seq data from IMR90 cells, average mHCG/HCG fractions (g, h) and uGCH/GCH fractions (i, j) were computed from forward and reverse complement sequences aligned to MNase-seq derived nucleosome midpoints. Nucleosomes within CpG Islands were excluded from this analysis