Fig. 1
From: Assessing histone demethylase inhibitors in cells: lessons learned
Position of KDMs in phylogenetic tree of 2-OG-dependent oxygenases. a Phylogenetic tree of the catalytic domains of human 2-OG oxygenases adapted according to [5]. The different subfamilies of KDMs are indicated. Non-KDM oxygenases are in grey. Proteins for which IF assays are described herein are highlighted in red. b Domain organization of 2-OG-dependent oxygenases for which IF assays are presented. The identities of the different domains are: JmjC Jumonji C domain, JmjN Jumonji N domain, PHD plant homeodomain, TDR tudor domain, C5HC2 zinc finger C5HC2 type, LRR leucine-rich repeat, TCZ treble-clef zinc finger domain