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Fig. 1 | Epigenetics & Chromatin

Fig. 1

From: Decoupling the downstream effects of germline nuclear RNAi reveals that H3K9me3 is dispensable for heritable RNAi and the maintenance of endogenous siRNA-mediated transcriptional silencing in Caenorhabditis elegans

Fig. 1

MET-2, SET-25, and SET-32 are required for the dsRNA-triggered H3K9me3 response at oma-1. a H3K9me3 levels in different samples are plotted as a function of position along the oma-1 locus. The WT response (oma-1 RNAi) is shown in all panels, except the top one (WT with gfp RNAi), to facilitate comparison with mutant ones. A yellow block indicates the region targeted by dsRNA. b–f Scatter plots that compare whole-genome H3K9me3 levels in oma-1 RNAi and gfp RNAi samples at 1 kb resolution for WT and various mutant strains. oma-1 regions (2 kb) and GRH loci (215 kb) are highlighted. Curved dotted lines indicate the twofold change (FDR < 0.05). Synchronized young adult animals (19 °C) were used throughout this study

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Epigenetics & Chromatin

ISSN: 1756-8935