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Fig. 10 | Epigenetics & Chromatin

Fig. 10

From: PRC2 is required for extensive reorganization of H3K27me3 during epigenetic reprogramming in mouse fetal germ cells

Fig. 10

Gene expression profiles remained normal after H3K27me3 enrichment was reduced in fetal male germ cells. a Average H3K27me3 intensities were measured using flow analysis of FACS sorted E12.5 germ cells cultured for 72 h with a vehicle control (DMSO; green) or 10 μm GSK126 (blue). bd Expression microarray relative probe signal intensities normalized to Sdha, Canx and Mapk1 for genes expressed in E12.5 germ cells cultured for 72 h with DMSO or 10 μm GSK126: b Hoxb locus. c A selection of male germ cell development genes; Sox2, Pou5f1, Nanog, Dppa2, Dppa4, Tdrd5, Piwil2, Tdrd7, Nanos2, Dnmt3l, Mvh. d PRC2 genes; Ezh1, Ezh2, Eed and Suz12. Values ± SEM; n = 3 for each treatment

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