Fig. 6

a Left representative pictures from hematoxylin and eosin staining of visceral white adipose tissue sections in wild-type (WT) and macroH2A1.2 Tg (Tg) mice fed with a HF diet. Right quantification of adipocyte area (μm²). b Leptin blood levels, measured by ELISA (Milliplex) in the four mice groups upon killing. Data are expressed as mean ± S.E.M. (n = 8–9 per group). *p < 0.05, ***p < 0.001 change versus WT fed a chow diet; ^# p < 0.01 change versus WT fed a HF diet. c Adipose gene expression profiling expressed in fold change and relative to HF diet compared to chow diet either in WT or in Tg mice. Results are represented as means of 3 mice per condition (WT, WT + HF diet, Tg, Tg + HF diet). All differences, with the exception of BMP7 and WNT5B (not significant), are highly significant (p < 0.0001)