Fig. 3

Metabolic phenotyping of macroH2A1.2 Tg mice. a CT scan of a representative WT and macroH2A1.2 Tg mouse (upper panels), image-assisted quantification of body length (lower panel); b lean and fat masses were determined by CT scan c representative pictures of WT and macroH2A1.2 Tg mice fed a chow diet (upper panels) or a HF diet (lower panels) mice, with a dorsal view (left panels) and a ventral view of peritoneal cavity showing internal organs upon killing (right panels); d body weight in WT and macroH2A1.2 Tg mice fed a chow or a HF diet at the experimental end point; e visceral fat ratio as determined by EchoMRI/CT scan in the four mice groups; f food intake in the four mice groups was assessed; g respiratory CO2/O2 exchange ratio as determined by metabolic cages; h IGF-1 blood levels, measured by ELISA (Milliplex) upon killing. Data are expressed as means} S.E.M. (n = 8–9 per group). *p < 0.05, ***p < 0.001 change versus WT fed a chow diet; ^## p < 0.01 change versus WT fed a HF diet