Fig. 4

LET-418 binding sites are enriched in activating chromatin marks genome-wide. a–c, e–g Ngsplot genome-wide binding profiles of embryonic LET-418 compared with the indicated histone marks, for the entire coding-gene population, or for the list of LET-418-enriched (peaks) or non-enriched (no peak) genes. Plots were calculated relative to the TSS or gene body position, depending on the histone mark. Activating histone marks are represented with green lines, whereas repressive marks are represented with red lines. d, h Ngsplot of LET-418 and embryonic ASH-2, a COMPASS component (d), or the transcriptional activator histone variant HTZ-1 (h), relative to the TSS position. Y axis: read count per million mapped reads