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Fig. 3 | Epigenetics & Chromatin

Fig. 3

From: The cancer-associated CTCFL/BORIS protein targets multiple classes of genomic repeats, with a distinct binding and functional preference for humanoid-specific SVA transposable elements

Fig. 3

Repeats preferentially bound by CTCF are comprised mostly of evolutionary older high-copy repeats. a A chart of repeat types from Additional file 1: Table S2 that are strongly bound by CTCF (×4 enrichment or more by ChIP-chip) but are not enriched for BORIS (×1 enrichment or less). b An example of the distribution of ChIP-seq tag enrichment for CTCF and BORIS at a tandem repeat of two different Alu (shown in the schematic). The centers of normalized counts were binned along the DNA sequence (histogram bars) with the fit line applied accordingly. c An example of ChIP-seq tag enrichment distribution for BORIS and CTCF at an intrachromosomal run of ~10 alpha-satellites (CENP-B box containing repeats are colored red). The histogram bars and smooth line—as in b

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Epigenetics & Chromatin

ISSN: 1756-8935