Fig. 5
From: Chromatin variation associated with liver metabolism is mediated by transposable elements
TE-associated chromatin variation impacts the expression of liver metabolic genes. a Top enriched biological processes of variable chromatin sites overlapping TEs, other repeats or non-repetitive (unique) sequences. The full list of enriched biological pathways is in Additional file 1: Table S3. Genomic coordinates of accessible chromatin sites were used as input for genomic regions enrichment of annotations tool (GREAT) analysis (see “Methods” section). b Genome browser view of TE-associated variable chromatin sites within the MUP locus. c Genome browser view of an LTR-associated variable chromatin site upstream of Ugt2b37. The guide RNAs designed for CRISPR-Cas9 deletion, and 170-mer mappability tracks of BALB/cJ pseudo-genome are shown below. d Quantitative polymerase chain reaction (qPCR) of Ugt2b37 expression levels in control or ΔLTR.Ugt2b37 H2.35 cells (*indicates p < 0.05, Student’s t test)