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Table 3 Features of validated differentially methylated positions (DMPs)

From: Oestrogen receptor β regulates epigenetic patterns at specific genomic loci through interaction with thymine DNA glycosylase

DMP Genomic location CGI Promoter MEFs Promoter ESCs Enhancer MEFs Enhancer ESCs
Hypo1 Intergenic No H3K4m3/H3K27m3 H3K4m3 H3K4m1  
Hypo2 (Dyx1c1) Promoter region Yes H3K4m3 H3K4m3   
Hypo3 Intragenic (intron) No    H3K4m1  
Hypo4 Intragenic (intron) No    H3K4m1  
Hypo5 Intragenic (intron) No H3K4m3   H3K4m1/H3K27ac H3K4m1
Hypo6 Promoter region No H3K27m3 H3K27m3 H3K4m1 H3K4m1/H3K27ac
Hypo7 Intragenic (intron) Yes H3K4m3/H3K27m3 H3K27m3   H3K4m1
Hypo8 (HoxD9) Promoter region Yes H3K4m3/H3K27m3 H3K4m3/H3K27m3 H3K4m1  
Hypo9 Promoter region Yes H3K4m3/H3K27m3 H3K4m3 H3K4m1/H3K27ac  
Hypo10 Promoter region Yes H3K4m3/H3K27m3 H3K4m3/H3K27m3 H3K4m1/H3K27ac H3K4m1
Hyper1 (HoxA9) Promoter region No H3K4m3 H3K4m3/H3K27m3   
Hyper2 (HoxA10) Promoter region No H3K4m3/H3K27m3 H3K27m3   H3K4m1
Hyper3 Promoter region No H3K4m3/H3K27m3 H3K27m3   H3K4m1
Hyper4 (Tnfaip2) Promoter region Yes H3K4m3 H3K4m3 H3K4m1 H3K4m1
Hyper5 Intragenic (intron) No     
Hyper6 (Pitx1) Promoter region Yes H3K4m3/H3K27m3 H3K4m3/H3K27m3   H3K4m1
Hyper7 Intragenic (intron) No     
Hyper8 Intergenic Yes H3K4m3 H3K4m3 H3K4m1  
  1. Genomic location, presence of a CpG island (CGI), and comparison with datasets for histone modifications enriched at promoter or enhancer regions in MEFs and embryonic stem cells (ESCs) using GenomeInspector (Genomatix). Hypo and hyper refer to hypo- and hypermethylation, respectively