Table 2 Gene ontology (GO) enrichment analysis of genes whose promoter is either hyper- or hypomethylated
GO term | p value | # Genes (63 in total) |
|---|---|---|
Hypermethylated genes | ||
Embryonic morphogenesis | 4.91E−04 | 5 |
Embryonic appendage morphogenesis | 6.39E−04 | 3 |
Embryonic limb morphogenesis | 6.39E−04 | 3 |
Regulation of transcription, DNA dependent | 7.62E−04 | 8 |
Regulation of RNA metabolic process | 8.50E−04 | 8 |
Transcription, DNA dependent | 1.01E−03 | 8 |
RNA biosynthetic process | 1.03E−03 | 8 |
Appendage morphogenesis | 1.12E−03 | 3 |
Limb morphogenesis | 1.12E−03 | 3 |
Embryonic development | 1.19E−03 | 6 |
GO term | p value | # Genes (223 in total) |
|---|---|---|
Hypomethylated genes | ||
Developmental process | 5.29E−10 | 52 |
Multicellular organismal development | 2.70E−09 | 48 |
Anatomical structure development | 4.73E−09 | 44 |
System development | 1.93E−08 | 41 |
Regulation of transcription from RNA polymerase II promoter | 6.70E−08 | 20 |
Regulation of transcription, DNA dependent | 7.84E−08 | 27 |
Regulation of RNA metabolic process | 1.10E−07 | 27 |
Positive regulation of cellular biosynthetic process | 1.42E−07 | 20 |
Transcription from RNA polymerase II promoter | 1.66E−07 | 20 |
Transcription, DNA dependent | 1.88E−07 | 27 |