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Table 1 Ubiquitous reduction or overexpression of dKDM5/LID results in a loss of viability

From: The histone demethylase dKDM5/LID interacts with the SIN3 histone deacetylase complex and shares functional similarities with SIN3

 

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Adult progeny observed

% Viable (UAS-X/

Act-GAL4)

Adult progeny observed

% Viable (UAS-X/

Act-GAL4)

Temp (°C)

UAS line

(UAS-X/Act-GAL4)

(UAS-X/CyO)

(UAS-X/Act-GAL4)

(UAS-X/CyO)

25

UAS-LID RNAi-KK(2)

41

180

17.3 ± 13.3

90

165

49.6 ± 9.5

UAS-LID RNAi-TRiP(1)

0

48

0

1

53

1.9

27

UAS-LID RNAi-KK(2)

0

54

0

5

63

13.5 ± 9.6

UAS-LID RNAi-TRiP(3)

0

168

0

0

237

0

UAS-LID (4)

0

228

0

0

194

0

UAS-LID-JmjC* (1)

0

63

0

0

52

0

  1. UAS-RNAi or UAS overexpression fly lines for lid were crossed with the Act-GAL4/CyO driver line and the progeny were analyzed and counted
  2. (n)Number of trials
  3. X genotype, KD knockdown, KK RNAi line from Vienna Drosophila RNAi Center, TRiP RNAi line from Bloomington Stock Center