Fig. 6

Genes regulated by SIN3, dKDM5/LID, or both under the induction of paraquat-mediated oxidative stress in S2 cells as determined by RNAseq. (a, c–e) Volcano plots depicting log fold change in expression. The total number of genes with significant changes in expression is displayed above the plot, while the number of upregulated genes is indicated to the right and downregulated genes to the left. b Gene ontology (GO) and pathway analysis of genes that change in expression upon induction of oxidative stress. Related GO terms with considerable overlap of genes have been combined. P < 0.01. f–h Venn diagrams indicating overlap of genes regulated by SIN3 and dKDM5/LID under normal and stress-induced conditions. KD knockdown, P paraquat