Characterization of whole-genome autosomal differences of DNA methylation between men and women

Table 3 Enriched GO terms among the sex-associated CpGs from the meta-analysis

GO ID	GO term	p value^a	Gene^b	No. of CpG probes^c
GO:0045820	Negative regulation of glycolysis	3.51E−07	HDAC4	393
			IER3	39
			FBP1	14
GO:0003085	Negative regulation of systemic arterial blood pressure	1.81E−06	ADRB1	8
			CALCA	40
			SOD2	7
			IER3	39
			BBS4	4
GO:0001562	Response to protozoan	2.69E−06	SLC11A1	20
			IL12B	12
			IER3	39

^a p value for enrichment, Bonferroni-corrected significance level of 3.08E−08
^bGenes annotated to the GO term restricted to those annotated to significant SMAs in KORA F4
^cNumber of CpG probes associated with each gene, according to Illumina’s annotation file; enrichment tests were corrected for the probe numbers (see “Methods”)

ISSN: 1756-8935