a Flowchart of the lobChIP procedure with timings used in the 1-day protocol. b–e Comparison of lobChIP to ENCODE data for histone modifications. b Clustering of read intensities at TSS for four different histone modifications from ENCODE (-E) and lobChIP. c PCA plot of the four different histone modifications, with ENCODE in dark colors and lobChIP in light colors. d Representative enrichment for H3K36me3, H3K4me3 and H3K27me3 over a 1 Mb window of chromosome 11. Corresponding ENCODE results are given as dense tracks above the RefSeq genes. e Scatter plot comparing lobChIP with ENCODE read counts for H3K27me3 in 40 kb windows centered at TSS.