Fig. 4
From: Wanderer, an interactive viewer to explore DNA methylation and gene expression data in human cancer
DNA methylation profile of the EN1 gene CpG island and flanking regions in colon (COAD) and breast carcinomas (BRCA). a Individual and mean methylation beta values of EN1 CpG island and the adjacent CpGs (chr2: 119,604,000–119,606,000). The region remains unmethylated in normal tissues and becomes hypermethylated in both colon and breast cancers. b Zooming out the region (chr2: 119,540,000–119,706,000) reveals the presence of a large number of CpG islands (green probes) and global hypermethylation of most of them in colon adenocarcinomas. Alternatively, breast cancers display interspersed regions of hypomethylation and hypermethylation. The graphs display the average methylation values of each dataset. Probes marked with an asterisk denote statistically significant differences between normal and tumor samples. Arrowheads indicate the position of the EN1 CpG island probes