Distinct spatial enrichments of PC-associated CpGs. (A) Spatial distribution of CpG probes around the TSS of genes that do not have any neighboring gene in 5Kbp. (B) Enrichment Z-scores of probes found at each distance for each PC projection threshold subset of probes, with respect to the background distribution. PC1 to PC3 probes showed a general trend of depletion around the TSS, while they were enriched away from it. PC4 probes were enriched around the TSS and depleted away from it. PC5 probes had a strong sign-dependent trend, positive projections were enriched close to the TSS and negative projections were enriched away from the TSS. PC, principal component; TSS, transcriptional start site.