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Figure 3 | Epigenetics & Chromatin

Figure 3

From: Concordant and discordant DNA methylation signatures of aging in human blood and brain

Figure 3

Hierarchical clustering of samples by PCs revealed distinct cluster patterns. Sample IDs indicate sample tissue, color tags (bottom) are mapped to the age of the individual (red: young, green: old). (A) Clustering of samples from a selection of all CpG sites with > 4σ variance across samples. The first cluster separated blood from brain. Inside the brain region, samples clustered by individual instead of tissue. (B) Clustering of samples from a selection of CpG sites with ± 4σ projections in PC1. (C) Clustering of samples from a selection of CpG sites with ± 4σ projections in PC4, an age-related PC. PC, principal component; BA10, Broadmann area 10; BA20, Broadmann area 20, BA7, Broadmann area 7; WB, whole blood.

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