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Figure 4 | Epigenetics & Chromatin

Figure 4

From: Pan-cancer stratification of solid human epithelial tumors and cancer cell lines reveals commonalities and tissue-specific features of the CpG island methylator phenotype

Figure 4

Characterization of CIMP in ENCODE cell lines. (A) Density plot of average site methylation for variably methylated in-CGI probes in cancer vs. non-cancer cell lines. (B) Same plot for probes in CGI shores and shelves. (C) Density plot showing standard deviation for variably methylated sites. (D) Heat map showing results from the CIMP classification algorithm. (E) Average cell line methylation computed over selected differentially methylated probes vs. average methylation computed over variably methylated probes. (F) PCA results showing samples projected onto the first two principal components and colored according to their CIMP status. (G) Average cell line methylation computed over variably methylated probes (vertical axis) vs. average methylation computed over set of 89 pan-cancer selected differentially methylated probes (horizontal axis).

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Epigenetics & Chromatin

ISSN: 1756-8935