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Figure 1 | Epigenetics & Chromatin

Figure 1

From: DNA demethylation by 5-aza-2′-deoxycytidine is imprinted, targeted to euchromatin, and has limited transcriptional consequences

Figure 1

Dose-dependent and imprinted demethylating effects of 5-aza-CdR. In panel (a), we show that global DNA methylation measured by LUMA is strongly depleted in a dose-dependent manner following 3 days of 5-aza-CdR exposure. In panel (b), we show that DNA methylation does not return to pre-exposure levels following a month of recovery in tissue culture despite (c) a return to pre-treatment cell growth rates (normalized to the untreated cells) and (d) a near-complete recovery of cell metabolic rate (using the WST-1 assay). 5-aza-CdR, 5-aza-2′-deoxycytidine.

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Epigenetics & Chromatin

ISSN: 1756-8935