ICG-001 and C646 affect many of the same genes in HCT116 and PANC1 cells. (A) Genes that were significantly detected in both HCT116 or in PANC1 cells (P value <0.01) were analyzed for expression differences caused by drug treatment. All genes having a differential P value <0.05 and a fold change greater than 1.2 were analyzed using Euclidean distance and hierarchical clustering. (B) Gene ontology analyses are shown for the genes commonly up- or downregulated in HCT116 and PANC1 cells by the drugs. Terms related to the cell cycle are shown in red. See Additional file 5 for a complete gene ontology analysis of the up- and downregulated genes.