Effects of epigenetic inhibitors on gene expression in PANC1 cells. (A) Genes differentially expressed after treatment of PANC1 cells with ICG-001 or C646 (see Figure 2) were analyzed using Euclidean distance and K-means clustering of expression fold change. (B) Gene ontology analyses are shown for the genes commonly up- and downregulated by both drugs and for the genes that are downregulated only by one of the drugs in PANC1 cells. Terms related to the cell cycle are shown in red. The numbers 1 to 6 in the brackets in panel A refer to different clusters that were used in the gene ontology analyses shown in Panel B (see Additional file 4).