Figure 5
From: Analysis of DNA methylation acquisition at the imprinted Dlk1 locus reveals asymmetry at CpG dyads
DNA methylation of the paternally-inherited Dlk1 -DMR is higher in the 14.5 d.p.c. placenta than in the 14.5 d.p.c. embryo, and is predominantly on the paternal allele at the IG- and Gtl2 -DMRs in placenta. Bisulfite mutagenesis and sequencing of DNA derived from B6 x CAST12 14.5 d.p.c. F1 hybrid placenta; details as described in Figure 2. (A) Analysis of DNA methylation at the Dlk1-DMR. For (B) and (C), the regions analyzed in this study correspond to IG-DMR region 1 and Gtl2-DMR region 5 analyzed by Sato et al. [12]. (B) Each circle represents one of 32 potentially methylated CpG dinucleotides at the IG-DMR, the first one located at position 110,766,345 (NC_000078.5). (C) Each circle represents one of 29 potentially methylated CpG dinucleotides at the Gtl2-DMR, the first one located at position 110,779,349 (NC_000078.5).