Table 1 Overview of the kinetic parameters in the model
From: Mechanistic stochastic model of histone modification pattern formation
Parameter | Description | Value (s-1) |
|---|---|---|
k on | Influx of transferases at initiation site | 2.4 (one enzyme models) |
0.01 (two enzyme models) | ||
k off | Release rate of transferase from nucleosome | 0.1 |
k transferase | Modification rate of nucleosome | 1000 |
k neighbor | Modification rate of neighboring nucleosome | 0.2 |
k slide | 1D diffusion rate over the chromatin | 0.6 |
k recruitment | Influx of transferases at modified nucleosome | 0.24-4.8 |
k demodification | Rate constant of demodification | 2.4 |
k interaction | Interaction frequency | 0.01-1 |