Table 3 List of top 20 hypermethylated CpG sites in the gene body of genes from high maternal folic acid diet
Chromosome | Start | End | Gene | Total CpG LMFA | Total CpG HMFA | Methylation difference | P value |
|---|---|---|---|---|---|---|---|
Male | Â | Â | Â | Â | Â | Â | Â |
Chr3 | 138455425 | 138455426 | Tspan5 | 15 | 20 | 0.90 | 0.00 |
Chr4 | 119140980 | 119140981 | Rimkla | 21 | 15 | 0.79 | 0.00 |
Chr4 | 119140989 | 119140990 | Rimkla | 37 | 16 | 0.77 | 0.00 |
Chr4 | 119141016 | 119141017 | Rimkla | 21 | 15 | 0.79 | 0.00 |
Chr4 | 119610724 | 119610725 | Hivep3 | 11 | 9 | 0.89 | 0.00 |
Chr8 | 87012542 | 87012543 | Cacna1a | 8 | 12 | 0.88 | 0.00 |
Chr8 | 94181294 | 94181295 | Fto | 28 | 22 | 0.79 | 0.00 |
Chr9 | 15678801 | 15678802 | Mtnr1b | 7 | 10 | 1.00 | 0.00 |
Chr9 | 106735686 | 106735687 | Vprbp | 12 | 12 | 1.00 | 0.00 |
Chr9 | 106735687 | 106735688 | Vprbp | 20 | 10 | 0.90 | 0.00 |
Chr9 | 110562402 | 110562403 | Ccdc12 | 14 | 22 | 0.86 | 0.00 |
Chr10 | 115535492 | 115535493 | Ptprr | 14 | 9 | 0.86 | 0.00 |
Chr13 | 84421455 | 84421456 | Tmem161b | 8 | 12 | 0.88 | 0.00 |
Chr13 | 93030034 | 93030035 | Msh3 | 363 | 63 | 0.83 | 0.00 |
Chr14 | 75232739 | 75232740 | Lrch1 | 18 | 10 | 0.89 | 0.00 |
Chr15 | 89378341 | 89378342 | Shank3 | 17 | 9 | 0.83 | 0.00 |
Chr18 | 37951652 | 37951653 | Pcdha4-g | 14 | 10 | 1.00 | 0.00 |
Chr18 | 60852504 | 60852505 | Ndst1 | 12 | 6 | 1.00 | 0.00 |
Chr18 | 65119073 | 65119074 | Nedd4l | 18 | 17 | 0.89 | 0.00 |
Chr19 | 31290367 | 31290368 | Prkg1 | 17 | 16 | 0.76 | 0.00 |
Female | Â | Â | Â | Â | Â | Â | Â |
Chr2 | 25434932 | 25434933 | Gm996 | 9 | 13 | 0.85 | 0.00 |
Chr3 | 30935498 | 30935499 | Prkci | 10 | 8 | 1.00 | 0.00 |
Chr3 | 103739555 | 103739556 | Rsbn1 | 9 | 15 | 0.89 | 0.00 |
Chr4 | 126102080 | 126102081 | Eif2c3 | 19 | 17 | 0.74 | 0.00 |
Chr4 | 140978449 | 140978450 | Hspb7 | 6 | 19 | 0.83 | 0.00 |
Chr4 | 150546918 | 150546919 | Camta1 | 22 | 6 | 0.83 | 0.00 |
Chr5 | 65200088 | 65200089 | Klf3 | 47 | 36 | 0.72 | 0.00 |
Chr5 | 103970283 | 103970284 | Ptpn13 | 23 | 12 | 0.74 | 0.00 |
Chr5 | 131698838 | 131698839 | Wbscr17 | 21 | 16 | 0.73 | 0.00 |
Chr7 | 53799845 | 53799846 | Sergef | 14 | 21 | 0.71 | 0.00 |
Chr8 | 35200739 | 35200740 | Leprotl1 | 25 | 10 | 0.76 | 0.00 |
Chr9 | 8001572 | 8001573 | Yap1 | 11 | 15 | 0.73 | 0.00 |
Chr9 | 42341123 | 42341124 | Grik4 | 39 | 30 | 0.73 | 0.00 |
Chr10 | 88898375 | 88898376 | Gas2l3 | 14 | 11 | 0.82 | 0.00 |
Chr11 | 3211676 | 3211677 | Gm11944 | 10 | 35 | 0.74 | 0.00 |
Chr11 | 115670841 | 115670842 | Caskin2 | 8 | 14 | 0.86 | 0.00 |
Chr14 | 58310412 | 58310413 | Lats2 | 6 | 24 | 1.00 | 0.00 |
Chr16 | 34322324 | 34322325 | Kalrn | 12 | 14 | 0.71 | 0.00 |
Chr17 | 86912790 | 86912791 | Prkce | 8 | 18 | 0.89 | 0.00 |
Chr19 | 25161873 | 25161874 | Dock8 | 16 | 12 | 0.75 | 0.00 |