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Table 3 List of top 20 hypermethylated CpG sites in the gene body of genes from high maternal folic acid diet

From: Single-base resolution of mouse offspring brain methylome reveals epigenome modifications caused by gestational folic acid

Chromosome Start End Gene Total CpG LMFA Total CpG HMFA Methylation difference P value
Male        
Chr3 138455425 138455426 Tspan5 15 20 0.90 0.00
Chr4 119140980 119140981 Rimkla 21 15 0.79 0.00
Chr4 119140989 119140990 Rimkla 37 16 0.77 0.00
Chr4 119141016 119141017 Rimkla 21 15 0.79 0.00
Chr4 119610724 119610725 Hivep3 11 9 0.89 0.00
Chr8 87012542 87012543 Cacna1a 8 12 0.88 0.00
Chr8 94181294 94181295 Fto 28 22 0.79 0.00
Chr9 15678801 15678802 Mtnr1b 7 10 1.00 0.00
Chr9 106735686 106735687 Vprbp 12 12 1.00 0.00
Chr9 106735687 106735688 Vprbp 20 10 0.90 0.00
Chr9 110562402 110562403 Ccdc12 14 22 0.86 0.00
Chr10 115535492 115535493 Ptprr 14 9 0.86 0.00
Chr13 84421455 84421456 Tmem161b 8 12 0.88 0.00
Chr13 93030034 93030035 Msh3 363 63 0.83 0.00
Chr14 75232739 75232740 Lrch1 18 10 0.89 0.00
Chr15 89378341 89378342 Shank3 17 9 0.83 0.00
Chr18 37951652 37951653 Pcdha4-g 14 10 1.00 0.00
Chr18 60852504 60852505 Ndst1 12 6 1.00 0.00
Chr18 65119073 65119074 Nedd4l 18 17 0.89 0.00
Chr19 31290367 31290368 Prkg1 17 16 0.76 0.00
Female        
Chr2 25434932 25434933 Gm996 9 13 0.85 0.00
Chr3 30935498 30935499 Prkci 10 8 1.00 0.00
Chr3 103739555 103739556 Rsbn1 9 15 0.89 0.00
Chr4 126102080 126102081 Eif2c3 19 17 0.74 0.00
Chr4 140978449 140978450 Hspb7 6 19 0.83 0.00
Chr4 150546918 150546919 Camta1 22 6 0.83 0.00
Chr5 65200088 65200089 Klf3 47 36 0.72 0.00
Chr5 103970283 103970284 Ptpn13 23 12 0.74 0.00
Chr5 131698838 131698839 Wbscr17 21 16 0.73 0.00
Chr7 53799845 53799846 Sergef 14 21 0.71 0.00
Chr8 35200739 35200740 Leprotl1 25 10 0.76 0.00
Chr9 8001572 8001573 Yap1 11 15 0.73 0.00
Chr9 42341123 42341124 Grik4 39 30 0.73 0.00
Chr10 88898375 88898376 Gas2l3 14 11 0.82 0.00
Chr11 3211676 3211677 Gm11944 10 35 0.74 0.00
Chr11 115670841 115670842 Caskin2 8 14 0.86 0.00
Chr14 58310412 58310413 Lats2 6 24 1.00 0.00
Chr16 34322324 34322325 Kalrn 12 14 0.71 0.00
Chr17 86912790 86912791 Prkce 8 18 0.89 0.00
Chr19 25161873 25161874 Dock8 16 12 0.75 0.00
  1. HMFA, high maternal folic acid; LMFA, low maternal folic acid.