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Table 2 List of hypomethylated CpG sites in the promoter of genes from high maternal folic acid diet

From: Single-base resolution of mouse offspring brain methylome reveals epigenome modifications caused by gestational folic acid

Chromosome Start End Gene Total CpG LMFA Total CpG HMFA Methylation difference P value
Male-CpG        
Chr2 104335383 104335384 Hipk3 6 10 -0.80 0.01
Chr2 118590048 118590049 A430105I19Rik 6 7 -0.83 0.00
Chr2 164156736 164156737 Svs5 5 6 -0.83 0.02
Chr2 171789984 171789985 1700028P15Rik 17 5 -0.80 0.00
Chr4 135283630 135283631 Il22ra1 5 5 -0.80 0.05
Chr5 122070856 122070857 Acad12 6 11 -0.73 0.01
Chr7 3219409 3219410 Mir291b 8 11 -0.75 0.00
Chr7 7253725 7253726 Clcn4-2 6 9 -0.72 0.01
Chr7a 15208940 15208941 Gm18756 10 12 -0.83 0.00
Chr7 91836603 91836604 2610206C17Rik 6 5 -0.83 0.02
Chr8 34495178 34495179 Purg 5 5 -0.80 0.05
Chr8 73034757 73034758 Uba52 6 6 -0.83 0.02
Chr8 77516944 77516945 Hmgxb4 6 15 -0.77 0.00
Chr9 66892554 66892555 Tpm1 15 6 -0.73 0.00
Chr10 53239171 53239172 Gm20597 8 7 -0.75 0.01
Chr12 3235150 3235151 1700012B15Rik 16 18 -0.88 0.00
Chr13 53382125 53382126 Ror2 6 5 -0.80 0.02
Chr13 53382128 53382129 Ror2 6 5 -1.00 0.00
Chr13 97839933 97839934 Fam169a 5 8 -0.75 0.02
Chr13 100671338 100671339 Cartpt 5 5 -0.80 0.05
Chr14 67628989 67628990 Bnip3l 7 8 -0.75 0.01
Chr19 5690281 5690282 Pcnxl3 20 13 -0.80 0.00
Female-CpG        
Chr2 127618583 127618584 1500011K16Rik 11 20 -0.85 0.00
Chr5a 100468191 100468192 Enoph1 11 5 -0.71 0.01
Chr6a 52196197 52196198 Hoxa11 5 5 -0.80 0.05
Chr6 100476908 100476909 1700049E22Rik 10 5 -0.80 0.00
Chr7 26326796 26326797 Ceacam2 6 15 -0.77 0.00
Chr7 29528469 29528470 Mrps12 16 5 -0.80 0.00
Chr7 86988105 86988106 Anpep 12 5 -0.83 0.00
Chr8 87469964 87469965 Rtbdn 7 6 -0.86 0.00
Chr8 116657191 116657192 Nudt7 14 5 -0.71 0.01
Chr9 109833746 109833747 Mtap4 8 14 -0.71 0.00
Chr10 76992742 76992743 Itgb2 8 7 -0.71 0.01
Chr10 80846466 80846467 Dohh 8 13 -0.69 0.00
Chr11 88727116 88727117 Akap1 6 5 -0.80 0.02
Chr11 115184397 115184398 Ush1g 12 5 -0.75 0.01
Chr11 118204319 118204320 BC100451 20 7 -0.81 0.00
Chr11 119909421 119909422 Aatk 7 5 -0.71 0.03
Chr11 120051942 120051943 2810410L24Rik 10 5 -0.70 0.02
Chr12 52447904 52447905 G2e3 8 5 -0.75 0.02
Chr14a 63380523 63380524 Ints6 5 6 -0.80 0.02
Chr15 81561248 81561249 Rangap1 13 5 -0.72 0.01
Chr17 52020946 52020947 Gm20098 9 7 -0.71 0.00
Chr18 38762241 38762242 Spry4 6 5 -0.83 0.02
Chr18 60933042 60933043 Rps14 9 8 -0.76 0.00
Chr19 7070128 7070129 Trpt1 8 6 -0.71 0.03
  1. aMethylation exclusively in the CpG island of promoter region. HMFA, high maternal folic acid; LMFA, low maternal folic acid.
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Epigenetics & Chromatin

ISSN: 1756-8935