Single-base resolution of mouse offspring brain methylome reveals epigenome modifications caused by gestational folic acid

Table 1 List of hypermethylated CpG sites in the promoter of genes from high maternal folic acid diet

Chromosome	Start	End	Gene	Total CpG LMFA	Total CpG HMFA	Methylation difference	P value
Male-CpG
Chr1	174430052	174430053	Tagln2	12	5	-0.80	0.00
Chr2	124976701	124976702	Slc12a1	9	10	-0.79	0.00
Chr2	163576501	163576502	Ada	7	5	-0.80	0.01
Chr5	110658438	110658439	Ankle2	10	6	-0.80	0.01
Chr7^a	25654980	25654981	Dmrtc2	5	5	-1.00	0.01
Chr12^a	112951515	112951516	Bag5	20	5	-0.80	0.00
Chr13	21533599	21533600	Pgbd1	11	5	-0.91	0.00
Chr14	12384528	12384529	Ptprg	15	6	-0.87	0.00
Chr16	4078495	4078496	Trap1	17	20	-0.85	0.00
Chr18^a	25327450	25327451	AW554918	11	10	-0.80	0.00
Chr18	55150289	55150290	Zfp608	8	5	-0.80	0.01
ChrX	70963189	70963190	Bcap31	15	7	-0.80	0.00
Female-CpG
Chr1	158239364	158239365	Nphs2	5	5	-0.80	0.05
Chr2	30141110	30141111	Nup188	10	9	-0.78	0.00
Chr2	93663150	93663151	Ext2	7	9	-0.78	0.00
Chr4	115456244	115456245	Atpaf1	10	5	-0.80	0.01
Chr7	4765788	4765789	Ube2s	12	14	-0.79	0.00
Chr7	116076508	116076509	Eif3f	8	10	-0.80	0.00
Chr9	43921237	43921238	Rnf26	10	6	-0.80	0.01
Chr9	43921243	43921244	Rnf26	10	6	-0.80	0.01
Chr9	70352700	70352701	Rnf111	7	6	-1.00	0.00
Chr11^a	106640875	106640876	Polg2	8	8	-0.75	0.01
Chr12^a	111517321	111517322	Dio3	8	8	-0.75	0.01
Chr13	3147545	3147546	Speer6-ps1	6	5	-0.80	0.02
Chr13	38751553	38751554	Eef1e1	10	6	-0.80	0.01
Chr16	18624289	18624290	Gp1bb	8	5	-0.75	0.02
Chr17	24806277	24806278	Zfp598	7	6	-0.86	0.00
Chr18^a	51277441	51277442	Prr16	7	5	-0.80	0.01
Chr18	60932782	60932783	Rps14	5	9	-0.78	0.02
ChrX	7721523	7721524	2900002K06Rik	6	13	-0.76	0.00
ChrX^a	155852426	155852427	Mtap7d2	14	17	-0.82	0.00

^aMethylation exclusively in the CpG island of promoter region. HMFA, high maternal folic acid; LMFA, low maternal folic acid.

ISSN: 1756-8935