Correlation of DNA methylation changes with gene expression alterations during dendritic cell (DC) differentiation. CG sites with significant DNA methylation changes were grouped by its relative distance to CGI. A. CpG island; B. CG shores: 0 to 2 kb from an island; C. Shelves: 2 to 4 kb from an island; D. Open sea: 4 kb away from an island. The changes in expression levels of differentially expressed genes (false discovery rate (FDR) <0.05) were then correlated with changes in beta values of differentially methylated points (DMPs), and Pearson’s correlation coefficients were reported for CG sites in each category. CG sites validated in Figure 2 whose associated gene expression levels also significantly altered were highlighted with different colors.