Drosophila linker histone H1 coordinates STAT-dependent organization of heterochromatin and suppresses tumorigenesis caused by hyperactive JAK-STAT signaling

Table 2 The tumor suppressor function of HP1 and Su(var)3-9 is dependent on H1

Genotype	N	Tumor index	p value
hop ^Tum-l /+	180	0.67
hop^Tum-l/+; ht-HP1/+	169	0.21
hop^Tum-l/+; ht-HP1/pINT1-H1^4M, Act-GAL4	113	0.62	<0.0001
hop^Tum-l/+; ht-Su(var)3-9/+	224	0.19
hop^Tum-l/+; ht-Su(var)3-9/pINT1-H1^4M, Act-GAL4	93	0.61	<0.0001

hop^Tum-l/FM7C flies were mated to wild type or homozygous transgenic ht-HP1 or ht-Su(var)3-9 flies; hop^Tum-l/FM7C; pINT1-H1^4M, Actin-GAL4/CyO flies were mated to homozygous transgenic ht-HP1 or ht-Su(var)3-9 flies. All crosses were set at 29°C. The tumor index in adult progeny of the appropriate genotype was calculated as described previously[18]. p values were calculated by Mann-Whitney test. N number of flies scored.

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