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Table 2 Conservation of the EZH2α and EZH2β isoforms across species

From: Functional characterization of EZH2β reveals the increased complexity of EZH2 isoforms involved in the regulation of mammalian gene expression

RefSeq

Species

Common name

EZH2α/NP_004447.2

% identity

EZH2β/NP_694543.1

% identity

NP_004447.2

Homo sapiens

Human

100.0

94.0

NP_694543.1

Homo sapiens

Human

94.0

100.0

XP_002923814.1

Ailuropoda melanoleuca

Giant panda

98.7

92.7

XP_002923815.1

Ailuropoda melanoleuca

Giant panda

92.6

98.3

NP_001179953.1

Bos taurus

Cow

97.6

91.8

NP_496992.3

Caenorhabditis elegans

Worm

23.8

23.4

XP_003496992.1

Cricetulus griseus

Chinese hamster

96.6

92.3

XP_003496993.1

Cricetulus griseus

Chinese hamster

96.2

90.3

XP_002751914.1

Callithrix jacchus

Marmoset

97.9

93.5

XP_002751915.1

Callithrix jacchus

Marmoset

92.6

98.3

XP_003432121.1

Canis lupus familiaris

Dog

97.9

93.5

XP_003432122.1

Canis lupus familiaris

Dog

96.7

92.3

XP_003432123.1

Canis lupus familiaris

Dog

92.6

98.3

XP_855891.2

Canis lupus familiaris

Dog

86.9

92.3

XP_855935.2

Canis lupus familiaris

Dog

91.0

86.5

NP_001137932.1

Drosophila melanogaster

Fruit fly

53.6

51.9

NP_524021.2

Drosophila melanogaster

Fruit fly

53.6

51.9

NP_001070747.1

Danio rerio

Zebrafish

84.0

80.6

XP_001504679.1

Equus caballus

Horse

98.7

94.2

XP_001504681.1

Equus caballus

Horse

93.5

99.4

XP_003364921.1

Equus caballus

Horse

97.5

93.0

XP_003364922.1

Equus caballus

Horse

91.7

87.3

XP_003640793.1

Gallus gallus

Red jungle fowl

91.2

97.0

XP_418879.3

Gallus gallus

Red jungle fowl

96.1

92.0

XP_001097572.2

Macaca mulatta

Rhesus monkey

98.0

93.6

XP_002803555.1

Macaca mulatta

Rhesus monkey

99.2

94.8

XP_002803556.1

Macaca mulatta

Rhesus monkey

92.3

87.8

XP_002803557.1

Macaca mulatta

Rhesus monkey

94.0

100.0

XP_003204725.1

Meleagris gallopavo

Wild turkey

91.0

86.8

NP_001140161.1

Mus musculus

Mouse

97.1

91.3

NP_031997.2

Mus musculus

Mouse

97.6

93.3

XP_003270929.1

Nomascus leucogenys

Gibbon monkey

99.2

94.8

XP_003270930.1

Nomascus leucogenys

Gibbon monkey

92.3

87.8

XP_001505650.2

Ornithorhynchus anatinus

Platypus

90.4

86.1

XP_001505800.1

Ornithorhynchus anatinus

Platypus

92.3

98.2

XP_003428414.1

Ornithorhynchus anatinus

Platypus

97.3

93.0

XP_003428415.1

Ornithorhynchus anatinus

Platypus

92.3

98.2

XP_002711987.1

Oryctolagus cuniculus

Rabbit

98.3

93.8

XP_002711988.1

Oryctolagus cuniculus

Rabbit

93.1

99.0

XP_002711989.1

Oryctolagus cuniculus

Rabbit

97.9

91.9

NP_001098571.1

Oryzias latipes

Killifish

82.0

78.6

XP_002818672.1

Pongo abelii

Sumatran orangutan

95.5

90.7

XP_001165949.1

Pan troglodytes

Chimpanzee

92.3

87.8

XP_001166099.1

Pan troglodytes

Chimpanzee

94.0

100.0

XP_001166174.2

Pan troglodytes

Chimpanzee

99.2

94.8

XP_003318915.1

Pan troglodytes

Chimpanzee

98.0

93.6

NP_001128451.1

Rattus norvegicus

Rat

97.5

93.2

NP_001231238.1

Sus scrofa

Wild pig

96.7

92.2

NP_001017293.1

Xenopus tropicalis

Western clawed frog

93.2

89.0

  1. Human EZH2α and EZH2β were aligned against all predicted EZH2 isoforms across species to determine the degree of conservation. The highest scoring correlations for each species and the two isoforms are indicated. Global alignment with free ends gap was performed using the Geneious alignment tool with BLOSUM62 matrix constrained by an open gap penalty of 12 and gap extension penalty of 3.