Figure 6
From: Epigenetic coordination of signaling pathways during the epithelial-mesenchymal transition
The translational readout of the epithelial-mesenchymal transition-related gene clusters (EMT-GCs) forms a modular protein-protein interaction network of EMT signaling (EMT-network). The EMT-network is based on experimentally determined interactions and induced by genes from the EMT-GCs. Nodes are genes from the EMT-GCs and additional genes that directly mediate their interactions. Node sizes are proportional to PageRank scores. Genes with high scores are network hubs. The EMT-network is partitioned into eight modules, four of them labeled and color-coded. The predominant functional characteristic of each module is indicated. The side table lists genes with the highest PageRanks in each of the four core modules.